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Hajime Sasaki, Ph.D., D.D.S.

(He/him/his)
Associate Professor
Cariology, Restorative Sciences and Endodontics
hajimes@umich.edu

Biography

I am a dentist-scientist and an Associate Professor in Endodontics at the University of Michigan School of Dentistry. My research focus is “dental inflammology” for prevention and cure of dental inflammations; The central goal of my research is to develop novel therapeutic approaches for the prevention and treatment of inflammation-associated diseases and to provide the suitable environment for wound healing and tissue regeneration. Dental inflammations are a consequence of highly complex biological processes including (but not limited to) infection, immune response, bone remodeling, and obesity-associated complications. As PI or co- Investigator/collaborator on institutional- and NIH-funded grants, I have laid the foundation for the dental inflammation research through investigation of disease phenotypes in highly reproducible mouse models, the genome-wide gene expression analyses in these models, and relevant follow-up studies.

Research

The role of serum amyloid A (SAA) in periapical lesions and obesity/obesity-associated complications.
More specifically, I purse a therapeutic potential of SAA-neutralization for inhibition of the development of obesity and obesity associated complications including insulin resistance.

Links

Michigan Research Experts Profile
Condition Focus
Prediabetes
Obesity
Type 2 Diabetes
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Population Focus
Men
Women
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Center, Institute, and Program Affiliations
Caswell Diabetes Institute
Michigan Diabetes Research Center
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Career Track
Basic Research
Translational Research
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