In response to growth factors and nutrients, target of rapamycin (TOR) plays essential roles in a wide array of cellular processes including protein synthesis, lipid and nucleotide biogenesis, gene transcription, apoptosis, and autophagy. Dysregulation of the mechanistic/mammalian TOR (mTOR) signaling pathway is involved in the development of various human diseases including cancer and metabolic disorders.

Using biochemical and genetic approaches, we investigate the function and regulation of the mTOR signaling pathway and the role of mTOR signaling in the development of human health problems.