My long-term goal is to identify key regulators of liver lipid metabolism and their roles in fatty liver disease. At the University of Michigan, I have been focusing on the metabolic actions of E4BP4 in liver metabolism. Our team has contributed to the original findings of how hepatic E4BP4 regulates metabolism in the liver, supporting the critical role of E4BP4 in the pathogenesis of fatty liver disease. We uncovered that E4BP4 represses hepatic hormone Fgf21 expression via histone methyl-transferase G9a in the liver. We reported that insulin potently induces E4bp4 to promote de novo lipogenesis via the classical AKT-mTORC1-SREBP-1c pathway in hepatocytes. Furthermore, we successfully generated an E4bp4 conditional knockout mouse line to study its tissue-specific functions in regulating metabolism. Our most study highlighted how ER stress-induced E4BP4 contributes to lipid accumulation in the liver using the liver-specific E4bp4 knockout mouse model.